You said you're having other hosts with the same config running happy.
If you have a chance to do so, check the FC adapter bios settings on affected host and another "reference host" that has the same hardware to see if there are any differences. This is just a wild guess but to me it seems like your host is having trouble with accessing that boot LUN after reboot or the LUN contents have been modified.
I would file a support ticket with VMware meanwhile.
WBR
Imants